Blood biochemical parameters in mice under the action of polyphosphate esters and their complexes with antibiotics

Complexes of polyphosphate esters with antibiotics were developed in Lviv Polytechnic National University together scientists Institute Animal Biology NAAS to reduce the negative impact on animal body. The conducted experiments allow assessing effect antibiotics, and complexes body laboratory animals based biochemical markers hepato- nephrotoxicity. administered average daily therapeutic doses. It was found that physiological state mice their blood indicators within normal values after administration ester P4 P4+antibiotics (amoxicillin, oxytetracycline, doxycycline). At same time, intramuscular P6 P6+antibiotics have a certain mice, which is manifested by changes activity marker enzymes: aspartate aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP). We an increase AST ALT activities. P6+amoxicillin P6+oxytetracycline increased ALP activity. decreased ALP. Blood urea content 38.5%, 26.9%, P6+doxycillin 21.8%. complex caused significant 237% concentration creatinine mice. other experimental groups fell range. Conducted studies characteristics under action new nanobiopolymer transporters ensured selection antibacterial drugs low toxicity.